Principles and concepts to include radiation effects on cellular, organ, system and levels within the entire body. Emphasis of the theories and principles of tolerance dose, time-dose relationships, fractionation schemes and the relationship to clinical practice of radiation therapy.
- Describe direct and indirect interactions between radiation and cells.
- Describe the molecular basis of cellular radiosensitivity.
- Explain the influence of cell cycle, repair, repopulation and reoxygenation on tissue radiosensitivity.
- Describe the components of a cell survival curve.
- Given clinical data, draw a cell survival curve.
- Differentiate between cell survival curves of varying LET radiations, hypoxic and aerated cells as well as cell cycle phases.
- Identify the acute and late effects of radiation on living tissue.
- Describe the effects of whole body radiation.
- Describe the long term effects of radiation.
- Explain the effects of radiation on the developing embryo and fetus at each stage.
- Explain the effects of time, dose and fractionation on long term side effects and treatment effectiveness.
- Describe the relationship between LET, RBE and OER.
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