Dr. Gabriel Pineda

School of Health and Human Services
Health Sciences

Dr. Pineda earned a Ph.D. in Genetics and Development at the University of Texas Southwestern Medical Center at Dallas, M.S. degree in Biology from the University of Texas El Paso, and a B.S. in Microbiology from the University of Texas at Austin. After graduating from the University of Texas at Austin he completed his medical technology training and is board certified by the American Society of Clinical Pathology.

Dr. Pineda completed two competitive postdoctoral fellowships at the University of California San Diego. The first was in the laboratory of Dr. Jean Wang at the Moores Cancer Center, where he was funded by an NIH Cancer Therapeutics (CT2) fellowship to study the co-transcriptional regulation of RNA polyermase II in response to DNA damage by ionizing radiation in cancer cells. His second postdoctoral position in the laboratory of Dr. Catriona Jamieson in the Division for Regenerative Medicine was funded by an NIH IRACDA teaching fellowship. There he learned and applied the scientific teaching method in various undergraduate courses at San Diego State University. His research focus contributed to the understanding of cancer stem cell biology in myeloproliferative disorders. His graduate studies were also funded by a competitive NIH fellowship in the Howard Hughes laboratory of Dr. James Chen at UT Southwestern were he focused on studying key signaling pathways involved in innate immunity. Specifically, understanding how ubiquitin mediates the regulation of NF-KappaB signaling. Before joining National University as full-time faculty, he taught courses in biology and microbiology as an adjunct faculty.

At National University, Dr. Pineda teaches Clinical Hematology (CLS 410), Clinical Microbiology (CLS 405), Survey of Bioscience (BIO 100 and BIO 100A), and Microbiology (Bio 203 and Bio 203A). Dr. Pineda has a strong record of mentoring undergraduates and actively encourages participation in independent research projects. Dr. Pineda challenges his students, with excitement and enthusiasm in clinical lab sciences, to help them reach their full potential. Dr. Pineda is seeking interested students to pursue research projects related to the field of myeloproliferative disorders and clinical laboratory sciences. Dr. Pineda maintains numerous collaborations with scientists in the Torrey Pines Mesa area of San Diego.

His peer-reviewed publications include articles in the Scientific Reports, BMC Research, Journal of Translational Medicine, Cell Stem Cell, Nature, Molecular Cell, and Proceedings of the National Academy of Sciences. His passion for teaching is evident in his training in scientific teaching and his attendance at the HHMI/NAS Summer Institute for Undergraduate education in Biology. He has presented as alumni at the HHMI/NAS Summer Institute for Undergraduate education in Biology at Boulder, CO. He continues to participate in learning new scientific teaching methods through active participation in Summer Institute activities. Dr. Pineda now resides in San Diego and in his spare time enjoys spending time with his family, fishing, open water swimming, and hiking.

Most Recent Publications

Zipeto MA, Court AC, Sadarangani A, Delos-Santos NP, Balaian L, Chun H-J, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q and Jamieson CHM. (2016) ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis, Cell Stem Cell, http://dx.doi.org/10.1016/j.stem.2016.05.004

Pineda G, Lennon K, Delos-Santos P N, Lambert-Fliszar F, Riso L G, Lazari E, Marra A M, Morris S, Sakaue-Sawano A, Miyawak A, and Jamieson C H. (2016) “Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche. Sci. Rep. 6, 23885; doi: 10.1038/srep23885. PMID: 27041210

Pineda G, Shen Z, Ponte de Albuquerque C, Reynoso E, Chen J, Tu C-C, Tang W, Lee S, Zhou H, Briggs S, Wang JYJ, (2015) “Proteomics Studies of the Interactome of RNA Polymerase II C-Terminal Repeated Domain".  BMC Res Notes. Oct 29;8:616. doi: 10.1186/s13104-015-1569-y. PMID: 26515650

Sadarangani A, Pineda G, Lennon KM, et al. (2015) GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. Mar 21;13:98. doi: 10.1186/s12967-015-0453-9. PMID: 25889765

Xia Z-P, Sun L, Xiang C, Pineda G, Jiang, X Adihkari A, Zeng W, and Chen ZJ, (2009) "Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains" Nature 461: 114-119. Sep 3;461(7260):114-9. doi: 10.1038/nature08247. PMID: 19675569

Pineda G, Ea C-K, and Chen ZJ, (2007) "Ubiquitination and TRAF Signaling" Adv. Exp. Med. Biol. 597: 80-92. PMID: 17633019

Ea C-K, Deng L, Xia Z-P, Pineda G, and Chen ZJ, (2006) "Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO" Mol. Cell 22: 245-257. PMID: 16603398 (Nominated for 2006: Signaling Breakthroughs of the Year, Science Stke)

Li X-D, Sun L, Seth RB, Pineda G, and Chen, ZJ, (2005) "Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade the innate immunity" PNAS 102: 17717-17722. PMID: 16301520

Wooldridge JB, Pineda G, Banuelas-Ornelas,JJ, Dagda KR, Gasanov ES, Rael DE, Lieb SC (2001).  "Mojave rattlesnakes (Crotalus scutulatus scutulatus) lacking the acidic subunit DNA sequence lack Mojave toxin in their venom" Comp. Biochem. Physiology Part B. 130: 169 – 179. PMID: 11544087

Contact Details

School of Health and Human Services
gpineda@nu.edu
(858) 309-3548