CLS1220X Serology Didactic Lectures

Course Description

Clinical Serology rotation consists of a wide range of laboratory disciplines such as Chemistry, Microbiology, Biochemistry,and Molecular Diagnostics. The objective of the rotation is to provide the student with the basic skills needed to perform a range of diagnostic serological tests independently, accurately, and efficiently. The student will also acquire knowledge of laboratory management and Quality control procedures.

Learning Outcomes

  • Identify role of WBC's in the immune system.
  • The student will discuss and explain how immunoglobulins function in immunological reactions.
  • Discuss various aspects of the field of Immunology.
  • Specimen requirements and handling of various types of specimens, in particular specimens for Serology, differentiate the blood collection vacutainers and their usage. Describe the collection and handling and transportation of major clinical specimens.
  • At the conclusion of this lecture series, the student will will be able to explain::
    The role of T and B lymphocytes in autoimmune disease states, name autoimmune disorders and related organs, compare types I,II,III, IV hypersensitivity reactions.
  • Different applications of radial immunodiffusion and complement fixation tests for diagnosing Cocciodiodies, describe the principle of Febrile agglutination procedures, discuss the etiology of and epidemiology signs and symptoms of various febrile, Rickettsial and Lyme Disease states.
  • The etiology, epidemiology, signs, and symptoms of primary, secondary, latent, and late Syphilis, discuss the principles and methodology of the RPR test, and the standard STS test procedure ( in detail), and discuss principles, technique, clinical application of the FTA-ABS, discussion of several newer methods for Syphilis detection, and microscopic techniques to discover and describe the spirochete responsible for causing Syphilis.
  • At the conclusion of this lecture series, the student will be able to discuss in depth:
    The causes of hepatitis, name the serological markers for a typical Hepatitis panel, and name the viruses responsible for causing hepatitis, modes of transmission, and preventive measures.
  • The complement fixation test in detail, name radial agar gel immunodiffusion techniques and describe various immunoglobulin precipitin lines found, discuss serum andamp;amp;nbsp;tube precipitin test, discuss the various immunoglobulins involved in the disease state of Coccioioides ( Iga, IgM, IgG, other), and discuss newest methods used to detect antibodies to Coccioioidies immitis disease states.
  • The components of the HIV virus, identify the epidemiologic factors relating to infections of HIV, explain the markers of an HIV infection, HIV variability and latest testing methodology, and discuss rapid tests in detail and the differences between them, discuss current antibiotic protocols for treating HIV and the need to alter these protocols to maintain the effectiveness of the treatment protocol.